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KMID : 0903519990420040336
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
1999 Volume.42 No. 4 p.336 ~ p.343
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Inhibitory Activities of Basidiomycetes on Prolyl Endopeptidase , Acetylcholine Esterase and Coagulation
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이경복/Lee, Kyung Bok
김종식/송경식/이인구/이현진/허건영/Kim, Jong Sik/Song, Kyung Sik/Rhee, In Koo/Lee, Hyun Jin/Heo, Gun Young
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Abstract
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Fifty six mycelial cultured Basidiomycetes were screened for their inhibitory effects against prolyl endopeptidase(PEP), acetylcholine esterase(AChE) and thrombus coagulation. Out of them, methanolic extract of mycelium and/or ethylacetate(EtOAc) soluble fraction from culture broth of Peniophora quercina, Amanita aspera, Phellinus chrysoloma, Grifola frondosa, Wolfiporia extensa, Clavicorona pyxidata and Phanerochaete sordida inhibited more than 90% of PEP activity at 40 ppm. The extracts of Lenzites betulina, Phellinus chrysoloma, Wolfiporia extensa, Phanerochaete sorrlida, Hypocrea nigricans, Coriolus azureus, Flammulina velutipes, Phlebiopsis gigantea and Bondarzewia montana exhibited about 40% of inhibitory activity against AChE at 40 ppm. In thrombin times assay, the extracts of Amanita aspera, Oxyporus latemarginata, Peniophora quercina, Fomes fomenfarius, Trametes versicolor, and Phlebiopsis gigantea delayed coagulation of thrombus about two to three times over control at ca 550 ppm. In activated partial thromboplastin times assay, none of the tested Basidiomycetes showed significant effect.
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